Prucalopride Improves Bowel Function and Colonic Transit Time in Patients With Chronic Constipation: An Integrated Analysis
Identifieur interne : 000224 ( Main/Exploration ); précédent : 000223; suivant : 000225Prucalopride Improves Bowel Function and Colonic Transit Time in Patients With Chronic Constipation: An Integrated Analysis
Auteurs : Anton Emmanuel [Royaume-Uni] ; Marina Cools [Belgique] ; Lieve Vandeplassche [Belgique] ; René Kerstens [Belgique]Source :
- The American Journal of Gastroenterology [ 0002-9270 ] ; 2014.
Abstract
Constipation is often characterized by slow colonic transit, but the relationship between colonic transit time (CTT) and symptoms is unclear. The aims of this study were to investigate the effect of prucalopride, a 5-hydroxytryptamine receptor-4 agonist, on CTT and assess the relationship between CTT and symptoms.
This was an integrated analysis of three randomized, placebo-controlled, phase 2 dose-finding trials of prucalopride in patients with chronic constipation (ClinicalTrials.gov identifiers: NCT00617513; NCT00631813; and NCT00596596). Measurements of CTT were analyzed using radio-opaque markers at the start and end (4 or 12 weeks) of treatment. At these visits, patients assessed the presence and severity of their symptoms.
In total, 280 patients had CTT measurements before and at the end of treatment and were included in the analysis. Their mean age was 43 years, 93% were women, and mean duration of constipation was 19 years. After a once daily treatment with prucalopride 2 mg (
There was a clear relationship between increased CTT and increased symptom severity in patients with chronic constipation. Treatment with prucalopride accelerated CTT in these individuals.
Url:
DOI: 10.1038/ajg.2014.74
PubMed: 24732867
PubMed Central: 4050523
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Vandeplassche, Lieve" sort="Vandeplassche, Lieve" uniqKey="Vandeplassche L" first="Lieve" last="Vandeplassche">Lieve Vandeplassche</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Shire-Movetis NV</institution>, Turnhout,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerstens, Rene" sort="Kerstens, Rene" uniqKey="Kerstens R" first="René" last="Kerstens">René Kerstens</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Shire-Movetis NV</institution>, Turnhout,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24732867</idno><idno 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sortKey="Emmanuel, Anton" sort="Emmanuel, Anton" uniqKey="Emmanuel A" first="Anton" last="Emmanuel">Anton Emmanuel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>GI Physiology Unit, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cools, Marina" sort="Cools, Marina" uniqKey="Cools M" first="Marina" last="Cools">Marina Cools</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Shire-Movetis NV</institution>, Turnhout,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vandeplassche, Lieve" sort="Vandeplassche, Lieve" uniqKey="Vandeplassche L" first="Lieve" last="Vandeplassche">Lieve Vandeplassche</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Shire-Movetis NV</institution>, Turnhout,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kerstens, Rene" sort="Kerstens, Rene" uniqKey="Kerstens R" first="René" last="Kerstens">René Kerstens</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Shire-Movetis NV</institution>, Turnhout,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">The American Journal of Gastroenterology</title><idno type="ISSN">0002-9270</idno><idno type="eISSN">1572-0241</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives:</title><p>Constipation is often characterized by slow colonic transit, but the relationship between colonic transit time (CTT) and symptoms is unclear. The aims of this study were to investigate the effect of prucalopride, a 5-hydroxytryptamine receptor-4 agonist, on CTT and assess the relationship between CTT and symptoms.</p></sec><sec><title>Methods:</title><p>This was an integrated analysis of three randomized, placebo-controlled, phase 2 dose-finding trials of prucalopride in patients with chronic constipation (ClinicalTrials.gov identifiers: NCT00617513; NCT00631813; and NCT00596596). Measurements of CTT were analyzed using radio-opaque markers at the start and end (4 or 12 weeks) of treatment. At these visits, patients assessed the presence and severity of their symptoms.</p></sec><sec><title>Results:</title><p>In total, 280 patients had CTT measurements before and at the end of treatment and were included in the analysis. Their mean age was 43 years, 93% were women, and mean duration of constipation was 19 years. After a once daily treatment with prucalopride 2 mg (<italic>n</italic>=98) and 4 mg (<italic>n</italic>=70), CTT was reduced by 12.0 h (95% confidence interval (CI): –18.9, –5.1) and 13.9 h (95% CI: –20.5, –7.4), respectively; CTT increased by 0.5 h (95% CI: –4.5, 5.5) with placebo (<italic>n</italic>=112). At the end of the trial, symptoms including bloating/flatulence/distension and straining were rated as severe or very severe by a higher proportion of patients with slow or very slow CTT (>48 h) than by those with normal CTT.</p></sec><sec><title>Conclusions:</title><p>There was a clear relationship between increased CTT and increased symptom severity in patients with chronic constipation. 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sortKey="Roy, Aj" uniqKey="Roy A">AJ Roy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiarioni, G" uniqKey="Chiarioni G">G Chiarioni</name></author><author><name sortKey="Salandini, L" uniqKey="Salandini L">L Salandini</name></author><author><name sortKey="Whitehead, We" uniqKey="Whitehead W">WE Whitehead</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Emmanuel, Anton" sort="Emmanuel, Anton" uniqKey="Emmanuel A" first="Anton" last="Emmanuel">Anton Emmanuel</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Cools, Marina" sort="Cools, Marina" uniqKey="Cools M" first="Marina" last="Cools">Marina Cools</name></noRegion><name sortKey="Kerstens, Rene" sort="Kerstens, Rene" uniqKey="Kerstens R" first="René" last="Kerstens">René Kerstens</name><name sortKey="Vandeplassche, Lieve" sort="Vandeplassche, Lieve" uniqKey="Vandeplassche L" first="Lieve" last="Vandeplassche">Lieve Vandeplassche</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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